"Stepping Out of the Shadows: The History of the RNA World"

Although as late as 1942 the possibility that bacteria were endowed with genetic material was held in doubt, the molecularization of biology led to the acknowledgement of the key role that RNA molecules play in major biological processes and to discuss the idea that RNA could have preceded DNA as genetic material. It was not until the late 1960s when Rich, Woese, Orgel and Crick suggested independently that RNA molecules could exhibit catalytic activity, as is now well established—but did life start with an RNA World?

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